Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Julie Delaloye; Irma J A De Bruin; Katharine E A Darling; Marlies Knaup Reymond; Fred C G J Sweep; Thierry Roger; Thierry Calandra; Matthias Cavassini

doi:10.1016/j.cyto.2012.07.027

Increased macrophage migration inhibitory factor (MIF) plasma levels in acute HIV-1 infection

Cytokine. 2012 Nov;60(2):338-40. doi: 10.1016/j.cyto.2012.07.027. Epub 2012 Aug 13.

Authors

Julie Delaloye¹, Irma J A De Bruin, Katharine E A Darling, Marlies Knaup Reymond, Fred C G J Sweep, Thierry Roger, Thierry Calandra, Matthias Cavassini

Affiliation

¹ Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Julie.Delaloye@chuv.ch

PMID: 22898393
DOI: 10.1016/j.cyto.2012.07.027

Abstract

Considering macrophage migratory inhibitory factor (MIF) as a critical pro-inflammatory cytokine of the immune system, we evaluated plasma MIF levels in 89 HIV-infected adults. Plasma MIF levels were higher in HIV-infected than in HIV-negative individuals. Highest MIF levels were observed during acute HIV infection (AHI) whilst patients on antiretroviral therapy (ART) had lower MIF levels, regardless of ART efficacy. Our results suggest that MIF is an integral component of the cytokine storm characteristic of AHI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Aged
Female
HIV Infections / blood*
HIV Seronegativity
Humans
Intramolecular Oxidoreductases / blood*
Macrophage Migration-Inhibitory Factors / blood*
Male
Middle Aged

Substances

Macrophage Migration-Inhibitory Factors
Intramolecular Oxidoreductases
MIF protein, human