Effect of diet on the low-grade and chronic inflammation associated with obesity and metabolic syndrome

Abstract

Adipose tissue is an active endocrine and paracrine organ that releases a large number of cytokines and biomarkers, which are involved in the development of chronic diseases. These effects have been attributed to direct or indirect mechanisms acting on insulin resistance, inflammation and endothelial dysfunction. In addition, the expression and secretion of these biomarkers in various tissues can be influenced by dietary patterns, with an effect on inflammatory status. In this context, following an energy-balanced diet, moderate in carbohydrates, high in oleic and omega-3 fatty acids, and low in saturated and trans fatty acids, with high intake of fruits and legumes and moderate alcohol consumption, appears to have beneficial effects on the inflammatory state associated with obesity and the manifestations of metabolic syndrome. However, the long-term impact of habitual intake and the mechanisms involved in distinct physiological and pathological conditions remain unclear.