Abstract
Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aging / pathology
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Basal Ganglia / blood supply
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Basal Ganglia / pathology
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Basal Ganglia Diseases / epidemiology
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Basal Ganglia Diseases / immunology
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Basal Ganglia Diseases / pathology
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C-Reactive Protein / immunology*
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C-Reactive Protein / metabolism
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Cerebrovascular Circulation / immunology*
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Cerebrovascular Disorders / epidemiology
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Cerebrovascular Disorders / immunology*
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Cerebrovascular Disorders / pathology
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Demyelinating Diseases / epidemiology
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Demyelinating Diseases / immunology
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Demyelinating Diseases / pathology
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Dilatation, Pathologic / epidemiology
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Dilatation, Pathologic / immunology
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Dilatation, Pathologic / pathology
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Encephalitis / epidemiology
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Encephalitis / immunology*
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Encephalitis / pathology
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Female
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Humans
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Interleukin-6 / immunology*
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Interleukin-6 / metabolism
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Leukoencephalopathies / epidemiology
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Leukoencephalopathies / immunology
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Leukoencephalopathies / pathology
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Magnetic Resonance Imaging
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Male
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Microcirculation / immunology*
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Risk Factors
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Severity of Illness Index
Substances
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IL6 protein, human
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Interleukin-6
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C-Reactive Protein