Docetaxel-induced photo-recall phenomenon

Photodermatol Photoimmunol Photomed. 2012 Aug;28(4):222-3. doi: 10.1111/j.1600-0781.2012.00669.x.

Abstract

Photo-recall phenomenon is a phototoxic eruption occurring on areas of previous ultraviolet-induced solar erythema following a systemic administration of a drug. It has been mostly described with methotrexate but remains rare with other antineoplastic drugs. We describe a case of docetaxel-induced photo-recall skin rash in a woman treated for a non-small-cell lung cancer. Although the patient has refused to receive a second infusion, chemotherapy can be carried on with photoprotection and the use of topical and/or systemic corticosteroids. In contrast, radiation recall is a well-known reaction by oncologists, most of them may not be aware of a similar phenomenon called photo-recall phenomenon. Recognizing this entity may avoid misdiagnosing a drug allergy and should avoid inappropriate decisions of drug discontinuation.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adrenal Cortex Hormones / administration & dosage
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Dermatitis, Phototoxic / drug therapy
  • Dermatitis, Phototoxic / etiology*
  • Dermatitis, Phototoxic / pathology*
  • Docetaxel
  • Female
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Middle Aged
  • Taxoids / administration & dosage
  • Taxoids / adverse effects*

Substances

  • Adrenal Cortex Hormones
  • Antineoplastic Agents
  • Taxoids
  • Docetaxel