A case of daptomycin-induced immune thrombocytopenia

Antimicrob Agents Chemother. 2012 Dec;56(12):6430-1. doi: 10.1128/AAC.01787-12. Epub 2012 Oct 1.

Abstract

We report a case of severe daptomycin-induced immune thrombocytopenia in a patient treated for methicillin-resistant Staphylococcus epidermidis and ampicillin-resistant Enterococcus faecalis bacteremia acquired in an intensive care unit. Serum antibodies bound to platelets in the presence of daptomycin on flow cytometry. There was no evidence of other causes of thrombocytopenia. The patient died of brain herniation complicating extensive cerebral hemorrhage. To our knowledge, this is the first described case of daptomycin-induced thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Abscess / drug therapy
  • Abdominal Abscess / microbiology
  • Ampicillin Resistance
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Daptomycin / adverse effects*
  • Daptomycin / therapeutic use
  • Enterococcus faecalis
  • Fatal Outcome
  • Flow Cytometry
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / drug therapy
  • Humans
  • Intracranial Hemorrhages / etiology
  • Male
  • Mesenteric Veins
  • Methicillin-Resistant Staphylococcus aureus
  • Middle Aged
  • Platelet Transfusion
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / drug therapy
  • Shock, Septic / complications
  • Shock, Septic / drug therapy
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / immunology
  • Thrombocytopenia / therapy
  • Venous Thrombosis / complications

Substances

  • Anti-Bacterial Agents
  • Daptomycin