HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study

Mol Biol Rep. 2012 Dec;39(12):10873-9. doi: 10.1007/s11033-012-1984-2. Epub 2012 Oct 12.

Abstract

This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541-1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy cases were recruited. The above mentioned polymorphisms were genotyped; multivariate logistic regression was performed. HSP90 GG (His/His) genotype was associated with elevated breast cancer risk. Similarly, the allele dose-response model pointed to increase in breast cancer risk per G allele. HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models. The positive association between HSP90 G allele and breast cancer risk seemed to pertain to both premenopausal and postmenopausal women. With respect to survival analysis, none of the aforementioned polymorphisms was associated with either disease-free survival or overall survival. HSP90α Gln488His polymorphism seems to be a risk factor for breast cancer. On the other hand, our study did not point to excess risk conferred by HSPA8 1541-1542delGT, Hsp70-2 P1/P2 and HIF-1α C1772T.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Demography
  • Female
  • Gene Frequency / genetics
  • HSC70 Heat-Shock Proteins / genetics*
  • HSP70 Heat-Shock Proteins / genetics*
  • HSP90 Heat-Shock Proteins / genetics*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
  • Kaplan-Meier Estimate
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*
  • Proportional Hazards Models
  • Regression Analysis

Substances

  • HIF1A protein, human
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • HSP90 Heat-Shock Proteins
  • HSP90AA1 protein, human
  • HSPA1B protein, human
  • HSPA8 protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit