The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates

Abstract

The NF-κB signaling pathway is important in the regulation of physiological and malignant hematopoiesis. In this issue of Immunity, Brechmann et al. (2012) identify a phosphatase, PP4R1, that inhibits NF-κB activation in T cells and T cell lymphoma.