Pancreatic extra-gastrointestinal stromal tumour masquerading as a bleeding duodenal mass

BMJ Case Rep. 2012 Oct 19:2012:bcr2012007040. doi: 10.1136/bcr-2012-007040.

Abstract

We describe a 55-year-old man presenting to our institution with a gastrointestinal bleed. He was found to have a 5 cm pancreatic extra-gastrointestinal stromal tumours (EGISTs) eroding into the duodenum and ampulla of Vater. Pancreaticoduodenectomy was performed and the tumour was noted to be positive for CD117 and CD34 with six mitotic figures per 50/high-powered field. At 5 months postoperatively he is receiving treatment with imatinib and doing well. To the best of our knowledge, our patient is only the 18th case reported in the literature to date.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD34 / blood
  • Antineoplastic Agents / therapeutic use
  • Benzamides / therapeutic use
  • Diagnosis, Differential
  • Duodenal Neoplasms / diagnosis*
  • Duodenum / pathology*
  • Duodenum / surgery
  • Gastrointestinal Hemorrhage / diagnosis*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / surgery
  • Gastrointestinal Stromal Tumors / diagnosis*
  • Gastrointestinal Stromal Tumors / drug therapy
  • Gastrointestinal Stromal Tumors / surgery
  • Humans
  • Imatinib Mesylate
  • Male
  • Middle Aged
  • Mitosis
  • Pancreas / pathology*
  • Pancreas / surgery
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / surgery
  • Pancreaticoduodenectomy*
  • Piperazines / therapeutic use
  • Proto-Oncogene Proteins c-kit / blood
  • Pyrimidines / therapeutic use

Substances

  • Antigens, CD34
  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
  • Proto-Oncogene Proteins c-kit