Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

Khalijah Awang; Xe-Min Loong; Kok Hoong Leong; Unang Supratman; Marc Litaudon; Mat Ropi Mukhtar; Khalit Mohamad

doi:10.1016/j.fitote.2012.10.004

Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

Fitoterapia. 2012 Dec;83(8):1391-5. doi: 10.1016/j.fitote.2012.10.004. Epub 2012 Oct 23.

Authors

Khalijah Awang¹, Xe-Min Loong, Kok Hoong Leong, Unang Supratman, Marc Litaudon, Mat Ropi Mukhtar, Khalit Mohamad

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my

PMID: 23098876
DOI: 10.1016/j.fitote.2012.10.004

Abstract

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC(50) 11.5μM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aniline Compounds / chemistry*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Humans
Meliaceae / chemistry*
Molecular Structure
Spectrum Analysis
Steroids / chemistry*
Steroids / pharmacology
Triterpenes / chemistry*
Triterpenes / pharmacology

Substances

24(E)-cycloart-24-ene-26-ol-3-one
Aniline Compounds
Antineoplastic Agents, Phytogenic
Steroids
Triterpenes
nitralin