FOXA1 and breast cancer risk

Nat Genet. 2012 Nov;44(11):1176-7. doi: 10.1038/ng.2449.

Abstract

Many SNPs associated with human disease are located in non-coding regions of the genome. A new study shows that SNPs associated with breast cancer risk are located in enhancer regions and alter binding affinity for the pioneer factor FOXA1.

Publication types

  • Comment

MeSH terms

  • Apoptosis Regulatory Proteins
  • Breast Neoplasms / genetics*
  • Chromatin / genetics*
  • Female
  • Hepatocyte Nuclear Factor 3-alpha / genetics*
  • High Mobility Group Proteins
  • Humans
  • Receptors, Progesterone / genetics*
  • Trans-Activators

Substances

  • Apoptosis Regulatory Proteins
  • Chromatin
  • FOXA1 protein, human
  • Hepatocyte Nuclear Factor 3-alpha
  • High Mobility Group Proteins
  • Receptors, Progesterone
  • TOX3 protein, human
  • Trans-Activators