Overuse of paracetamol caffeine aspirin powders affects cerebral glucose metabolism in chronic migraine patients

Eur J Neurol. 2013 Apr;20(4):655-62. doi: 10.1111/ene.12018. Epub 2012 Oct 30.

Abstract

Background and purpose: Overuse of analgesic plays a prominent role in migraine chronification. Paracetamol caffeine aspirin (PCA) powders are commonly used in Chinese migraineurs. This study investigated the effects of the specific combination analgesic on cerebral glucose metabolism in chronic migraine (CM).

Methods: 18F-FDG-PET was used to measure regional metabolism in all subjects. Brain metabolisms of CM patients with analgesic overuse (AO-CM; n=10), no analgesic overuse (NAO-CM; n=10), and no regimen (NR-CM; n=10) and 17 age- and gender-matched normal controls (NC) were compared using statistical parametric mapping. Then, all patients underwent brain MRI analysis within 7 days after PET scans, as well as MMSE and MoCA scale for cognitive function tests.

Results: Glucose metabolic changes in CM patients taking different dosage of analgesic during headache-free periods and clear distinctions in several brain regions were observed. Patients with AO-CM exhibited significant metabolic reductions in thalamus, as well as increased metabolism in middle temporal gyrus and insula relative to NR-CM and NAO-CM. However, in these regions, no difference was observed in AO-CM except for increased metabolism in the right insula relative to NC group.

Conclusions: Overusing PCA powders affects regional brain glucose metabolism in CM. Increased metabolism in the right insula may be associated with recurrently overusing of PCA powders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / adverse effects*
  • Adult
  • Analgesics, Non-Narcotic / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspirin / adverse effects*
  • Brain / diagnostic imaging
  • Brain Chemistry / drug effects
  • Caffeine / adverse effects*
  • Central Nervous System Stimulants / adverse effects*
  • Chronic Disease
  • Female
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Headache Disorders, Secondary / metabolism*
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Migraine Disorders / diagnostic imaging
  • Migraine Disorders / drug therapy
  • Migraine Disorders / metabolism*
  • Neuropsychological Tests
  • Pain Measurement
  • Positron-Emission Tomography
  • Powders
  • Radiopharmaceuticals

Substances

  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Central Nervous System Stimulants
  • Powders
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Acetaminophen
  • Caffeine
  • Glucose
  • Aspirin