Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7297-301. doi: 10.1016/j.bmcl.2012.10.123. Epub 2012 Nov 5.

Abstract

We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / metabolism
  • Antiviral Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Drug Discovery*
  • Drug Evaluation, Preclinical
  • Drug Stability
  • Hepacivirus / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Pyrazoles / chemistry
  • Pyrazoles / metabolism
  • Pyrazoles / pharmacology*
  • Pyrimidines / chemistry
  • Pyrimidines / metabolism
  • Pyrimidines / pharmacology*
  • Rats
  • Structure-Activity Relationship

Substances

  • 7-aminopyrazolo(1,5-a)pyrimidine
  • Antiviral Agents
  • Pyrazoles
  • Pyrimidines