Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

J Cell Biol. 2012 Nov 26;199(5):755-70. doi: 10.1083/jcb.201202155. Epub 2012 Nov 19.

Abstract

Mitotic chromosome formation involves a relatively minor condensation of the chromatin volume coupled with a dramatic reorganization into the characteristic "X" shape. Here we report results of a detailed morphological analysis, which revealed that chromokinesin KIF4 cooperated in a parallel pathway with condensin complexes to promote the lateral compaction of chromatid arms. In this analysis, KIF4 and condensin were mutually dependent for their dynamic localization on the chromatid axes. Depletion of either caused sister chromatids to expand and compromised the "intrinsic structure" of the chromosomes (defined in an in vitro assay), with loss of condensin showing stronger effects. Simultaneous depletion of KIF4 and condensin caused complete loss of chromosome morphology. In these experiments, topoisomerase IIα contributed to shaping mitotic chromosomes by promoting the shortening of the chromatid axes and apparently acting in opposition to the actions of KIF4 and condensins. These three proteins are major determinants in shaping the characteristic mitotic chromosome morphology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Antigens, Neoplasm / metabolism*
  • Chickens
  • Chromatids / metabolism
  • Chromosomes / metabolism*
  • DNA Topoisomerases, Type II / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Kinesins / genetics
  • Kinesins / metabolism*
  • Mitosis*
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism*
  • Mutation
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Tumor Cells, Cultured

Substances

  • Antigens, Neoplasm
  • DNA-Binding Proteins
  • Multiprotein Complexes
  • Nuclear Proteins
  • chromokinesin
  • condensin complexes
  • Adenosine Triphosphatases
  • Kinesins
  • DNA Topoisomerases, Type II