Abstract
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin stabilization.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Binding Sites / genetics
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Frizzled Receptors / chemistry
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Frizzled Receptors / metabolism*
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Humans
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Low Density Lipoprotein Receptor-Related Protein-5 / chemistry
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Low Density Lipoprotein Receptor-Related Protein-5 / metabolism*
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Low Density Lipoprotein Receptor-Related Protein-6 / chemistry
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Low Density Lipoprotein Receptor-Related Protein-6 / metabolism*
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Models, Molecular*
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism*
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Protein Conformation*
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Wnt Proteins / chemistry
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Wnt Proteins / metabolism*
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Wnt Signaling Pathway / physiology*
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beta Catenin / chemistry
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beta Catenin / metabolism*
Substances
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Frizzled Receptors
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Low Density Lipoprotein Receptor-Related Protein-5
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Low Density Lipoprotein Receptor-Related Protein-6
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Multiprotein Complexes
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Wnt Proteins
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beta Catenin