Small RNAs of opposite sign… but same absolute value

Erik J Sontheimer

doi:10.1016/j.cell.2012.11.032

Small RNAs of opposite sign… but same absolute value

Cell. 2012 Dec 7;151(6):1157-8. doi: 10.1016/j.cell.2012.11.032.

Author

Erik J Sontheimer¹

Affiliation

¹ Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA. erik@northwestern.edu

PMID: 23217700
DOI: 10.1016/j.cell.2012.11.032

Abstract

In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for genome retention.

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