Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families

PLoS One. 2012;7(12):e52262. doi: 10.1371/journal.pone.0052262. Epub 2012 Dec 31.

Abstract

We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brazil
  • Chromosomes, Human, Pair 13 / genetics*
  • Female
  • Genetic Linkage / genetics*
  • Humans
  • Male
  • Pedigree*
  • Pilot Projects
  • Schizophrenia / genetics*
  • Statistics, Nonparametric
  • Young Adult

Grants and funding

This study was funded by Fundação de Amparo a Pesquisa do Estado de São Paulo (grant number 2011/00030-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.