Numerical simulation of particle dynamics in an orifice-electrode system. Application to counting and sizing by impedance measurement

Int J Numer Method Biomed Eng. 2013 Apr;29(4):462-75. doi: 10.1002/cnm.2528. Epub 2012 Nov 12.

Abstract

This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice-electrode system. The model allows to simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and to compute the voltage pulses generated by the modification of the inner dielectric medium. This approach gives important information about particles size distribution and allows to quantify the role of trajectory and orientation of particles on the size measurement.

MeSH terms

  • Blood Cell Count / instrumentation
  • Computer Simulation
  • Electric Impedance
  • Electrodes*
  • Microfluidic Analytical Techniques / instrumentation
  • Microfluidics / instrumentation*
  • Microfluidics / methods*
  • Models, Theoretical
  • Particle Size*