Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest.
Methods: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides.
Results: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity.
Conclusions: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.