First diastereoselective [3 + 2] cycloaddition reaction of diethyl isocyanomethylphosphonate and maleimides

Org Biomol Chem. 2013 Feb 13;11(10):1640-9. doi: 10.1039/c3ob26766k.

Abstract

Bicyclic α-iminophosphonates were prepared via the first diastereoselective silver catalyzed [3 + 2] cycloaddition reaction of diethyl isocyanomethylphosphonate and diversely N-substituted maleimides. The reduction of the resulting imine by catalytic hydrogenation led to cyclic α-aminophosphonates, which are α-aminoester surrogates. The relative stereochemistry of the adducts was confirmed by X-ray crystallographic analysis of . The diastereoselectivity of the cycloaddition reaction was rationalised by theoretical studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged Bicyclo Compounds / chemical synthesis*
  • Bridged Bicyclo Compounds / chemistry
  • Crystallography, X-Ray
  • Cyclization
  • Maleimides / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Organophosphonates / chemical synthesis*
  • Organophosphonates / chemistry
  • Quantum Theory
  • Stereoisomerism

Substances

  • Bridged Bicyclo Compounds
  • Maleimides
  • Organophosphonates