An aide memoire for model-based drug development--a new key for the interpretation of the erythromycin breath test--therapeutic index as a biomarker for smart drug development

MeSH terms

• Animals
• Anti-Bacterial Agents / pharmacokinetics*
• Biomarkers, Pharmacological*
• Drug Approval / methods*
• Drug Discovery / methods*
• Drug Discovery / trends*
• Drug-Related Side Effects and Adverse Reactions*
• Erythromycin / pharmacokinetics*
• Female
• Humans
• Male
• Organic Anion Transporters / genetics*
• Organic Anion Transporters, Sodium-Independent / genetics*
• Orphan Drug Production / methods*
• Pharmaceutical Preparations / administration & dosage*
• Research Design / standards*