A case of 6-week-old male infant with meningitis and concurrent bacteremia caused by Streptococcus gallolyticus subspecies pasteurianus (Streptococcus bovis biotype 11.2) is presented. The isolates were susceptible to all beta-lactam antibiotics. Nevertheless, delayed defervescence and lack of satisfactory clinical improvement after treatment with multiple beta-lactam antibiotics prompted the combination therapy of vancomycin and penicillin G. The patient completed a 2-week course of antibiotics and recovered uneventfully.