It is known that the developability of drugs is related to their physicochemical and DMPK properties. Given the time and expense involved in discovering and developing new drugs, maximizing the chance of success by calculating properties ahead of chemical synthesis and testing, and only acting on those candidates whose properties fall into a desired range, would seem to make sense. This paper provides an overview of calculable physicochemical and DMPK properties, an assessment of their relative difficulty of their calculation and accuracy, and available software. Methods companies have employed to communicate results will be discussed, including the use of composite scoring functions and ranking schemes. Calculations do no good if chemists will not use them to prioritize synthesis decisions. Strategies are presented for facilitating model usage. An approach adopted at Genentech for presenting results that involves the close coupling of property calculations with 3D structure based drug design is described.