Role of the nuclear receptor Tailless in adult neural stem cells

Mech Dev. 2013 Jun-Aug;130(6-8):388-90. doi: 10.1016/j.mod.2013.02.001. Epub 2013 Feb 13.

Abstract

Tailless (Tlx) is an orphan nuclear receptor which is specifically expressed in the neural stem cells of the two largest germinal neurogenesis zones in the adult mouse brain, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. By interacting with its cofactors, Tlx represses its target genes and plays an important role in the maintenance of adult NSCs. This review provides a snapshot of current knowledge about Tlx function in adult NSCs.

Publication types

  • Review

MeSH terms

  • Adult Stem Cells / cytology
  • Adult Stem Cells / metabolism*
  • Animals
  • Dentate Gyrus / cytology
  • Dentate Gyrus / embryology
  • Dentate Gyrus / metabolism*
  • Gene Expression Regulation, Developmental*
  • Lateral Ventricles / cytology
  • Lateral Ventricles / embryology
  • Lateral Ventricles / metabolism*
  • Mice
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neural Stem Cells / cytology
  • Neural Stem Cells / metabolism*
  • Neurogenesis
  • Protein Binding
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Signal Transduction

Substances

  • Nerve Tissue Proteins
  • Nr2e1 protein, mouse
  • Receptors, Cytoplasmic and Nuclear