Predictors of cognitive decline in 85-year-old patients without cognitive impairment at baseline: 2-year follow-up of the octabaix study

Am J Alzheimers Dis Other Demen. 2013 Mar;28(2):147-53. doi: 10.1177/1533317512475021. Epub 2013 Feb 18.

Abstract

Background/rationale: To determine how many 85-year-old community-dwelling patients with good cognitive performance at baseline maintain this level at 2-year follow-up.

Methods: We realized a longitudinal community-based study including 169 inhabitants. Patients who maintained scores >23 on the Spanish version of the Mini-Mental State Examination (MEC) were compared with the rest.

Results: A total of 144 individuals (85.2%) were found maintaining a MEC score >23. Under the combined criteria 110 (65%) presented no new cognitive decline. Multiple logistic regression analysis showed that maintaining a MEC score >23 was significantly associated with having a higher MEC score at baseline (P < .001, odds ratio 1.280, 95% confidence interval 1.104-1.484).

Conclusion: Most oldest-old patients with good cognitive function at baseline maintain this level at 2-year follow-up.

MeSH terms

  • Aged, 80 and over
  • Aging / physiology
  • Aging / psychology*
  • Cognition / physiology*
  • Cognition Disorders / diagnosis*
  • Cohort Studies
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • Humans
  • Logistic Models
  • Male
  • Mental Status Schedule
  • Prospective Studies
  • Risk Factors