Holoprosencephaly in clomiphene-induced pregnancy: a possible association? A case report and literature review

Clin Exp Obstet Gynecol. 2012;39(4):535-6.

Abstract

Clomiphene is widely used for inducing ovulation. Evidence for congenital abnormalities, in particular central nervous system defects (CNS-D) and in babies born from clomiphene-induced pregnancies is conflicting. The authors report a case of holoprosencephalia (HPE) in a fetus delivered from a mother receiving clomiphene.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Clomiphene / adverse effects
  • Clomiphene / pharmacology
  • Female
  • Fertility Agents, Female / adverse effects
  • Fertility Agents, Female / pharmacology
  • Fetal Diseases / chemically induced
  • Fetal Diseases / diagnostic imaging
  • Fetal Diseases / etiology*
  • Holoprosencephaly / chemically induced
  • Holoprosencephaly / diagnostic imaging
  • Holoprosencephaly / etiology*
  • Humans
  • Ovulation Induction*
  • Ultrasonography, Prenatal

Substances

  • Fertility Agents, Female
  • Clomiphene