IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

J Exp Med. 2013 Mar 11;210(3):491-502. doi: 10.1084/jem.20122006. Epub 2013 Mar 4.

Abstract

Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(-/-) OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B(+), have cytotoxic activity, and/ or produce interferon γ (IFN-γ). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-γ when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / drug effects*
  • CD8-Positive T-Lymphocytes / immunology
  • Female
  • Immunization
  • Immunologic Memory / drug effects*
  • Interferon-gamma / biosynthesis
  • Interleukin-1 / pharmacology*
  • Listeria monocytogenes / immunology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL

Substances

  • Interleukin-1
  • Interferon-gamma