Microcirculatory changes in venous disease

Phlebology. 2013 Mar:28 Suppl 1:73-8. doi: 10.1177/0268355513477025.

Abstract

Objective: The aim of this study was to investigate the feasibility to measure microcirculatory blood flow changes in patients with venous ulcers, by using the laser speckle imaging.

Methods: Nine patients with a leg ulcer were measured with the laser speckle imager in a sitting position before and after mimicking venous hypertension, with the legs raised, by applying a blood pressure cuff and inflating it to 60 mmHg.

Results: The results were inconclusive, due to the fact that a lot of practical problems interfered with the measurements, e.g. movement artefacts and inadequate wound visualisation.

Conclusion: The additional value of laser speckle imaging in daily practice for wound care still remains an important question for further research. A reliable, reproducible microcirculation measurement in venous ulcers might predict venous ulcer healing and recurrence and therefore would be a valuable diagnostic tool in daily practice.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Feasibility Studies
  • Female
  • Humans
  • Laser-Doppler Flowmetry / methods*
  • Male
  • Microcirculation*
  • Pilot Projects
  • Posture
  • Predictive Value of Tests
  • Prognosis
  • Regional Blood Flow
  • Reproducibility of Results
  • Skin / pathology
  • Varicose Ulcer / diagnosis*
  • Varicose Ulcer / pathology
  • Varicose Ulcer / physiopathology
  • Varicose Ulcer / therapy
  • Venous Insufficiency / diagnosis*
  • Venous Insufficiency / pathology
  • Venous Insufficiency / physiopathology
  • Venous Insufficiency / therapy
  • Venous Pressure
  • Wound Healing