Abstract
Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology*
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Drug Resistance, Bacterial
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Humans
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Isoniazid / pharmacology
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Microbial Sensitivity Tests / standards*
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification
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Nitro Compounds
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Sputum / microbiology
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Thiazoles / pharmacology*
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Tuberculosis, Pulmonary / microbiology
Substances
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Antitubercular Agents
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Nitro Compounds
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Thiazoles
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nitazoxanide
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Isoniazid