Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues

Jing-Jing Shi; Fei-Hong Ji; Pei-Lan He; Ya-xi Yang; Wei Tang; Jian-Ping Zuo; Yuan-Chao Li

doi:10.1002/cmdc.201300083

Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues

ChemMedChem. 2013 May;8(5):722-5. doi: 10.1002/cmdc.201300083. Epub 2013 Mar 19.

Authors

Jing-Jing Shi¹, Fei-Hong Ji, Pei-Lan He, Ya-xi Yang, Wei Tang, Jian-Ping Zuo, Yuan-Chao Li

Affiliation

¹ Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Road Zu Chong Zhi, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.

PMID: 23512654
DOI: 10.1002/cmdc.201300083

Abstract

FIGHTING HCV: Two potent antiviral analogues were developed from a previously identified lead as novel agents against hepatitis C virus. Their potency and selectivity (5 n: IC50 =0.013 μM and EC50 =0.018 μM; 5 t: IC50 =0.007 μM and EC50 =0.024 μM) make them good candidates for further development as antiviral agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Cell Line
Cell Survival / drug effects
Dose-Response Relationship, Drug
Hepacivirus / drug effects*
Humans
Indazoles / chemical synthesis
Indazoles / chemistry
Indazoles / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Structure-Activity Relationship
Virus Replication / drug effects

Substances

Antiviral Agents
Indazoles