The associations between serum paraoxonase 1 activity and carotid atherosclerosis in renal transplant patients

Clin Nephrol. 2013 Sep;80(3):198-202. doi: 10.5414/CN107855.

Abstract

Backgrounds and aims: Paraoxonase 1 (PON1) is a novel marker that has been shown to exert protective functions on atherosclerosis by preventing oxidative modification of serum lipoproteins. In this study, we investigated the effects of PON1 on CA-IMT in renal transplant patients.

Methods: A total of 98 adult renal transplant recipients was enrolled in the study. CA-IMT was determined by B-mode Doppler ultrasonography. PON-1 activity was assessed by the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol.

Results: Mean age was 39.4 ± 9.6 years and 10% of the patients were diabetic. Time after transplant was 76 ± 59 months. Mean PON1 level was 62.1 ± 43.3 U/l. PON1 levels were negatively correlated with CA-IMT and positively with HDL cholesterol. Mean CA-IMT was 0.62 ± 0.10 mm (0.40 - 0.98). CA-IMT was positively correlated with age, male gender and negatively with proteinuria and PON1 levels. In linear regression analysis, PON1 levels were associated with CA-IMT.

Conclusion: Reduced PON1 activity is significantly associated with increased carotid atherosclerosis in renal transplant patients.

MeSH terms

  • Adult
  • Aryldialkylphosphatase / blood*
  • Biomarkers / blood
  • Carotid Artery Diseases / blood
  • Carotid Artery Diseases / diagnostic imaging
  • Carotid Artery Diseases / enzymology
  • Carotid Artery Diseases / etiology*
  • Carotid Intima-Media Thickness
  • Cross-Sectional Studies
  • Down-Regulation
  • Female
  • Humans
  • Kidney Transplantation / adverse effects*
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Predictive Value of Tests
  • Risk Factors
  • Time Factors
  • Ultrasonography, Doppler
  • Young Adult

Substances

  • Biomarkers
  • Aryldialkylphosphatase
  • PON1 protein, human