Diamond-lipid hybrids enhance chemotherapeutic tolerance and mediate tumor regression

Adv Mater. 2013 Jul 12;25(26):3532-41. doi: 10.1002/adma.201300343. Epub 2013 Apr 15.

Abstract

Self-assembled nanodiamond-lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)-surface and small molecules, while providing a mechanism for cell-targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor-targeted NDLPs are highly biocompatible particles that provide cell-specific imaging, promote tumor retention of ND-complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.

Keywords: cancer; drug delivery; hybrid nanomaterials; nanodiamond; nanomedicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Drug Tolerance*
  • ErbB Receptors / metabolism
  • Female
  • Humans
  • Lipids / chemistry*
  • Mice
  • Nanodiamonds / chemistry*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Lipids
  • Nanodiamonds
  • EGFR protein, human
  • ErbB Receptors