The first total synthesis of nhatrangin A

Org Biomol Chem. 2013 Jul 21;11(27):4442-8. doi: 10.1039/c3ob40252e.

Abstract

The first total synthesis of nhatrangin A has been achieved. Pivotal bond forming events in the synthesis include Brown crotylboration, olefin cross-metathesis, Sharpless asymmetric dihydroxylation and Yamaguchi esterification.

MeSH terms

  • Alkenes / chemistry
  • Biological Products / chemical synthesis*
  • Cyanobacteria / chemistry*
  • Esterification
  • Hydroxylation
  • Lyngbya Toxins / chemical synthesis*
  • Stereoisomerism

Substances

  • Alkenes
  • Biological Products
  • Lyngbya Toxins
  • nhatrangin A