Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters"

Science. 2013 Apr 19;340(6130):273. doi: 10.1126/science.1231815.

Abstract

Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • DNA Polymerase II / metabolism*
  • Dosage Compensation, Genetic*
  • Drosophila / genetics*
  • Drosophila Proteins / metabolism*
  • Female
  • Genes, X-Linked*
  • Male
  • Promoter Regions, Genetic*
  • X Chromosome / genetics*

Substances

  • Drosophila Proteins
  • DNA Polymerase II