Redefining KSHV latency

Ohad Yogev; Chris Boshoff

doi:10.1016/j.chom.2013.04.003

Redefining KSHV latency

Cell Host Microbe. 2013 Apr 17;13(4):373-4. doi: 10.1016/j.chom.2013.04.003.

Authors

Ohad Yogev¹, Chris Boshoff

Affiliation

¹ Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Huntley Street, University College London, London WC1E 6BT, UK.

PMID: 23601098
DOI: 10.1016/j.chom.2013.04.003

Abstract

In this issue of Cell Host & Microbe, Chang and Ganem (2013) report that Kaposi's sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endothelial cells (BECs), activates mTORC1 signaling and sensitizes LECs to rapamycin-induced killing. The differential rapamycin sensitivity is explained by a unique LEC-specific virus latency program.

Publication types

Comment

Grants and funding

13100/CRUK_/Cancer Research UK/United Kingdom