Abstract
A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Line
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Cell Line, Tumor
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Choline / chemistry
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Choline / metabolism*
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Drug Delivery Systems
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Endocytosis*
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Ethers, Cyclic / chemistry
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Ethers, Cyclic / metabolism*
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Humans
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Models, Molecular
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Resorcinols / chemistry
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Resorcinols / metabolism*
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Solubility
Substances
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Ethers, Cyclic
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Resorcinols
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cavitand
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Choline