Aspirin-exacerbated respiratory disease: clinical disease and diagnosis

Abstract

This article summarizes the current knowledge in the field of clinical presentation and diagnosis of aspirin-exacerbated respiratory disease (AERD). The definition, prevalence, natural history, and clinical presentation of this distinct clinical syndrome are described. The classification and tolerance of particular groups of cyclooxygenase inhibitors by patients with AERD are presented. The authors comprehensively discuss provocation tests with aspirin as the most reliable method to confirm the diagnosis of AERD.