Rhodium(III)-catalyzed synthesis of cyclopenta[b]pyrroles from 1,2-diketones, 2-aminopyridine, and alkynes

Abstract

Pyrrole victory: Cyclopenta[b]pyrroles have been synthesized by the rhodium(III)-catalyzed oxidative annulative coupling of 1,2-diketones, 2-aminopyridine, and alkynes. This transformation can also be carried out in a one-pot sequence, thereby providing a quick and straightforward access to synthetically and pharmaceutically important cyclopenta[b]pyrroles.