Purpose: To explore the clinical significance of serum interleukin-27 (IL-27) level in patients with oral squamous cell carcinoma (OSCC).
Methods: Forty patients pathologically confirmed as OSCC were included, and 20 healthy adults were used as controls. The serum IL-27 were tested with enzyme -linked immunosorbent assay(ELISA). Statistical analysis was performed by SPSS10.0 software package and t test was used to determine the difference.
Results: The level of serum IL-27 in OSCC patients was significantly higher than that in the control group(P<0.05). The high expression of IL-27 correlated with clinical pathologic stage (P<0.05) and cervical lymph node metastasis (P<0.05).
Conclusion: The expression of serum IL-27 correlates significantly with the clinicopathologic stages of OSCC.