Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress

Clin Cancer Res. 2013 Jun 15;19(12):3111-3. doi: 10.1158/1078-0432.CCR-13-0800. Epub 2013 May 24.

Abstract

There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology*
  • Carcinoma, Renal Cell / drug therapy*
  • Female
  • Humans
  • Kidney Neoplasms / drug therapy*
  • Stearoyl-CoA Desaturase / metabolism*

Substances

  • Stearoyl-CoA Desaturase