Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma

J Clin Oncol. 2013 Jul 10;31(20):e341-4. doi: 10.1200/JCO.2012.47.6143. Epub 2013 Jun 3.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / therapy*
  • Adenocarcinoma of Lung
  • Aged
  • Biopsy, Needle
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Indoles / therapeutic use*
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / therapy*
  • Male
  • Multimodal Imaging / methods
  • Mutation*
  • Neoplasm Invasiveness / pathology
  • Neoplasm Staging
  • Pneumonectomy / methods
  • Polymerase Chain Reaction
  • Positron-Emission Tomography
  • Proto-Oncogene Proteins B-raf / genetics*
  • Radiotherapy, Adjuvant
  • Risk Assessment
  • Sulfonamides / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Vemurafenib

Substances

  • Indoles
  • Sulfonamides
  • Vemurafenib
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf