Small cell variant of anaplastic large cell lymphoma presenting as arm mass in a child: a rare entity with diagnostic challenge

J Cancer Res Ther. 2013 Apr-Jun;9(2):317-9. doi: 10.4103/0973-1482.113410.

Abstract

Anaplastic lymphoma kinase positive, anaplastic large cell lymphoma (ALCL) is an uncommon T-cell non-Hodgkin lymphoma. A rare morphological variant-small cell variant of ALCL may pose diagnostic challenge especially when it presents primarily as a soft tissue mass. We present a rare case of small cell variant of ALCL in a 14-year-old female presented with arm swelling with emphasis on clinical, morphological and immunohistochemical aspects. Pathologists should be aware of this entity when considering a differential diagnosis of malignant round cell tumor as early and correct diagnosis has important clinical implications.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anaplastic Lymphoma Kinase
  • Arm / pathology*
  • Female
  • Humans
  • Lymphoma, Large-Cell, Anaplastic / diagnosis*
  • Lymphoma, Large-Cell, Anaplastic / enzymology
  • Lymphoma, Large-Cell, Anaplastic / metabolism
  • Lymphoma, Large-Cell, Anaplastic / pathology*
  • Receptor Protein-Tyrosine Kinases / metabolism

Substances

  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Receptor Protein-Tyrosine Kinases