Abstract
GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16- natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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B-Lymphocytes / immunology*
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CD56 Antigen / analysis
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Flaviviridae Infections / diagnosis*
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Flaviviridae Infections / pathology
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Flaviviridae Infections / virology
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GB virus C / immunology*
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GPI-Linked Proteins / analysis
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HIV Infections / complications*
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Hepatitis, Viral, Human / diagnosis*
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Hepatitis, Viral, Human / pathology
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Hepatitis, Viral, Human / virology
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Humans
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Immune Tolerance
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Killer Cells, Natural / immunology*
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Monocytes / immunology*
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Receptors, IgG / analysis
Substances
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CD56 Antigen
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FCGR3B protein, human
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GPI-Linked Proteins
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NCAM1 protein, human
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Receptors, IgG