HLA-G 5' URR SNPs and 3' UTR 14-bp insertion/deletion polymorphism in an Afro-Brazilian population from Paraná State

L V Tureck; L C Santos; P F Wowk; S B Mattar; J S Silva; J C M Magalhães; V M M S Roxo; M G Bicalho

doi:10.1111/iji.12068

HLA-G 5' URR SNPs and 3' UTR 14-bp insertion/deletion polymorphism in an Afro-Brazilian population from Paraná State

Int J Immunogenet. 2014 Feb;41(1):29-33. doi: 10.1111/iji.12068. Epub 2013 Jul 7.

Authors

L V Tureck¹, L C Santos, P F Wowk, S B Mattar, J S Silva, J C M Magalhães, V M M S Roxo, M G Bicalho

Affiliation

¹ Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil.

PMID: 23829564
DOI: 10.1111/iji.12068

Abstract

The present study investigated 23 SNPs in the 5'URR promoter region and the 14 bp ins/del polymorphism at the 3'UTR region of the HLA-G gene in 150 individuals with Afro-Brazilian ancestry. Three haplotypes were found to be the most frequent. Comparing these polymorphisms in other samples, our data suggest that Afro-Brazilians are more similar to the Euro-Brazilians than to Hutterite population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3' Untranslated Regions*
5' Untranslated Regions
Alleles
Brazil
Ethnicity / genetics*
Female
Gene Frequency
Genetics, Population
Genotype
HLA-G Antigens / genetics*
Haplotypes
Humans
INDEL Mutation*
Male
Polymorphism, Single Nucleotide*

Substances

3' Untranslated Regions
5' Untranslated Regions
HLA-G Antigens