Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine

Chem Commun (Camb). 2013 Aug 18;49(64):7159-61. doi: 10.1039/c3cc43545h.

Abstract

Clostridium difficile is a leading cause of severe nosocomial infections. Cell-surface carbohydrate antigens are promising vaccine candidates. Here we report the first total synthesis of oligomers of the lipoteichoic acid antigen repeating unit. Synthetic glycan microarrays revealed anti-glycan antibodies in the blood of patients that help to define epitopes for vaccine development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Vaccines / chemical synthesis*
  • Bacterial Vaccines / chemistry
  • Bacterial Vaccines / pharmacology
  • Clostridioides difficile* / drug effects
  • Humans
  • Lipopolysaccharides / chemical synthesis
  • Lipopolysaccharides / chemistry*
  • Microarray Analysis
  • Polysaccharides / chemistry*
  • Polysaccharides / pharmacology
  • Polysaccharides / therapeutic use
  • Teichoic Acids / chemical synthesis
  • Teichoic Acids / chemistry*

Substances

  • Bacterial Vaccines
  • Lipopolysaccharides
  • Polysaccharides
  • Teichoic Acids
  • lipoteichoic acid