Metal-free oxidative hydroxyalkylarylation of activated alkenes by direct sp3 C-H functionalization of alcohols

Chem Commun (Camb). 2013 Sep 4;49(68):7540-2. doi: 10.1039/c3cc44055a.

Abstract

A metal-free tandem radical addition/cyclization reaction of activated alkenes and alcohols has been developed. The process provides an efficient and atom economical access to various valuable hydroxyl-containing oxindoles through the direct sp(3) C-H functionalization of alcohols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Alkenes / chemistry*
  • Cyclization
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Oxindoles

Substances

  • Alcohols
  • Alkenes
  • Indoles
  • Oxindoles
  • 2-oxindole