Whole genome sequencing of an unusual serotype of Shiga toxin-producing Escherichia coli

Tim Dallman; Lisa Cross; Chloe Bishop; Neil Perry; Bente Olesen; Kathie A Grant; Claire Jenkins

doi:10.3201/eid1908.130016

Whole genome sequencing of an unusual serotype of Shiga toxin-producing Escherichia coli

Emerg Infect Dis. 2013 Aug;19(8):1302-4. doi: 10.3201/eid1908.130016.

Authors

Tim Dallman¹, Lisa Cross, Chloe Bishop, Neil Perry, Bente Olesen, Kathie A Grant, Claire Jenkins

Affiliation

¹ Health Protection Agency, London, UK.

Abstract

Shiga toxin-producing Escherichia coli serotype O117:K1:H7 is a cause of persistent diarrhea in travelers to tropical locations. Whole genome sequencing identified genetic mechanisms involved in the pathoadaptive phenotype. Sequencing also identified toxin and putative adherence genes flanked by sequences indicating horizontal gene transfer from Shigella dysenteriae and Salmonella spp., respectively.

Keywords: Escherichia coli; O117:K1:H7; Shiga toxin–producing Escherichia coli; bacteria; gene transfer; pathogenicity; serotype; whole genome sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genome, Bacterial*
High-Throughput Nucleotide Sequencing
Humans
Likelihood Functions
Multilocus Sequence Typing
Phylogeny
Polymorphism, Single Nucleotide
Serotyping
Shiga-Toxigenic Escherichia coli / classification
Shiga-Toxigenic Escherichia coli / genetics*