Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

PLoS One. 2013 Jul 29;8(7):e69895. doi: 10.1371/journal.pone.0069895. Print 2013.

Abstract

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral / genetics*
  • Antigens, Viral / immunology*
  • Enterovirus / classification
  • Enterovirus / genetics*
  • Enterovirus Infections / virology
  • Humans
  • Phylogeny
  • Vietnam

Substances

  • Antigens, Viral

Grants and funding

The project was funded by National Health Research Institutes, Taiwan. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.