A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides

Chemistry. 2013 Sep 9;19(37):12245-8. doi: 10.1002/chem.201301774. Epub 2013 Aug 12.

Abstract

Cute CO! An interesting and straightforward procedure for the carbonylative synthesis of chromenones from readily available salicylic aldehydes and benzyl chlorides has been developed (see scheme; DPPP = 1,3-bis(diphenylphosphino)propane). In the presence of a palladium catalyst, various coumarins were produced in good to excellent yields.

Keywords: benzyl chlorides; carbonylation; chromenones; palladium; salicylic aldehydes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Benzyl Compounds / chemistry*
  • Catalysis
  • Chromones / chemical synthesis*
  • Chromones / chemistry*
  • Palladium
  • Phosphines / chemical synthesis*
  • Phosphines / chemistry*
  • Propane / analogs & derivatives*
  • Propane / chemical synthesis
  • Propane / chemistry
  • Salicylic Acid / chemistry*

Substances

  • Aldehydes
  • Benzyl Compounds
  • Chromones
  • Phosphines
  • 1,3-bis(diphenylphosphino)propane
  • Palladium
  • benzyl chloride
  • Salicylic Acid
  • Propane