The objective of this study was to examine the influence of Ramadan fast on appetite sensations, nutritional intakes and body weight in Malians with type 2 diabetes. Appetite sensations were assessed before Ramadan and then at the second, ninth, and sixteenth days of Ramadan (period). A total of 24 subjects recorded their appetite sensations every 2 h between 0800 and 2200 h using visual analogue scales. Daily energy intakes were estimated by a 48-h food recall (before and during Ramadan). Results showed a significant sex effect for desire to eat (p < 0.04) and a significant period effect for desire to eat and fullness (p < 0.01). Significant sex by period interactions were observed for fullness (p < 0.001), desire to eat (p < 0.01), and prospective food consumption (p < 0.03). Moreover, significant sex by period by time interactions were found for all appetite sensations (p < 0.007). Interaction effects were mainly explained by sex differences in appetite sensations before rather than during Ramadan. Although a significant body weight loss was observed in men and a significant decrease in waist circumference was found in women (p < 0.05), no significant changes in reported average daily energy intakes were observed in either men or women. According to these preliminary results, Ramadan fasting has an impact on appetite sensations that is probably not the same in men and women.