Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model

J Invest Dermatol. 2014 Mar;134(3):858-861. doi: 10.1038/jid.2013.374. Epub 2013 Sep 4.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Disease Models, Animal
  • Genes, Recessive
  • Humans
  • Ichthyosis, Lamellar / drug therapy*
  • Ichthyosis, Lamellar / genetics
  • Ichthyosis, Lamellar / pathology
  • Imidazoles / pharmacology*
  • Keratosis / drug therapy
  • Keratosis / genetics
  • Keratosis / metabolism
  • Organ Culture Techniques
  • Piperazines / pharmacology*
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Rats
  • Skin / pathology*

Substances

  • Imidazoles
  • Piperazines
  • nutlin 3
  • Mdm2 protein, rat
  • Proto-Oncogene Proteins c-mdm2